南方医科大学学报Issue(2)：265-269,5.
瘦素受体基因多态性与中国人群高血压相关性的meta分析
Association of leptin receptor gene polymorphisms with hypertension in Chinese population:a meta-analysis
摘要
Abstract
Objective To evaluate the association between leptin receptor gene polymorphisms and hypertension in Chinese population. Methods The keywords"Hypertension","Blood Pressure, high","Leptin Receptor","OB Receptor","LEPR Protein","CD295 Antigens", and "LEPR" were used to search the literature to identify the relevant studies for meta-analysis using software RevMan 5.0 and Stata 11.0 software. Results Thirteen studies involving 3210 cases of hypertension and 1881 controls were included in the meta-analysis. Overall, a significant association was found between Gln223Arg gene polymorphism and hypertension in allele contrast and dominant genetic model (for allele contrast genetic model: OR=1.17, 95%CI=1.48-2.15, P<0.0001;for dominant model:OR=2.18, 95%CI=1.75-2.72, P<0.00001). No statistically significant correlation was found between Lys109Arg polymorphism and hypertension (for allele model:OR=1.13, 95%CI=0.84-1.51, P=0.42;for recessive genetic model:OR=0.88, 95%CI=0.33-2.32, P=0.79;for dominant genetic model:OR=1.20, 95%CI=0.85-1.71, P=0.29;for additive genetic model:OR=0.90, 95%CI=0.34-2.42, P=0.84). Conclusion There is no significant correlation between Lys109Arg variant of LEPR gene and hypertension in Chinese population, but the Gln223Arg polymorphism is associated with hypertension in allele contrast and dominant genetic model. Chinese population with an A allele are at a high risk of developing hypertension.关键词
高血压/瘦素受体/基因多态性/meta分析Key words
hypertension/leptin receptor/gene polymorphism/meta-analysis引用本文复制引用
金楠,李革,李会,张帆,陈玲,冷冰..瘦素受体基因多态性与中国人群高血压相关性的meta分析[J].南方医科大学学报,2014,(2):265-269,5.基金项目
“十二五”国家科技支撑计划项目 （）
