南方医科大学学报Issue(3)：401-405,5.DOI:10.3969/j.issn.1673-4254.2014.03.23
208例低危型宫颈癌患者的辅助治疗及预后相关因素分析
Impact of postoperative adjuvant therapy on prognosis of low-risk cervical cancer:analysis of 208 cases
摘要
Abstract
Objective To investigate the effect of adjuvant chemotherapy on the prognosis of patients with low-risk cervical cancer (without pelvic lymph node metastasis, parametrial involvement, positive surgical margin, primary tumor size>4 cm, deep cervical stromal invasion, or lymph-vascular space invasion). Methods The clinical data of 208 patients with low-risk cervical cancer were studied retrospectively to analyze the indications of adjuvant chemotherapy and its relationship with tumor recurrence and the patients' survival. Results The median follow-up time of the cohort was 73 months. The overall tumor recurrence rate was 4.8%and the total 5-year survival rate of the patients was 96.0%. Sixty-nine of the patients received adjuvant chemotherapy (Taxol+Cisplatin) after the operation with a median of 2.5 (2-4) courses. Univariate analysis showed that the histological tumor grade was significantly associated with adjuvant chemotherapy (P<0.001). In the 114 grade III patients, 50 received adjuvant chemotherapy as compared with 19 in the 94 grade I-II patients. Among the grade III patients, no significant differences was found in the overall survival rate (97.0%vs 95.0%) or tumor recurrence rate (4.0%vs 4.7%) rate between the patients with adjuvant chemotherapy and those without. The tumor size (2 cm or less vs>2 cm) was significantly associated with tumor recurrence rate (1.1%vs 7.5%, P=0.034) and the overall 5-year survival rate (100.0%vs 93.0%, P=0.034) in the 208 patients. In the 139 patients receiving only surgical treatment, the tumor recurrence and 5-year survival rates were not significantly correlated with the histologic grade, age, FIGO staging, gross type, tumor size or histologic type. Conclusion There has been no sufficient evidence to support the prescription of postoperative adjuvant chemotherapy for low-risk cervical cancer based on histological grading of the tumor, which may not help in reducing tumor recurrence or improving the long-term survival of the postoperative patients.关键词
宫颈癌/化疗/组织学分级Key words
cervical cancer/chemotherapy/histological grade引用本文复制引用
孙菲,李艳芳,刘继红,熊樱..208例低危型宫颈癌患者的辅助治疗及预后相关因素分析[J].南方医科大学学报,2014,(3):401-405,5.基金项目
国家自然科学基金（81172484）@@@@Supported by National Natural Science Foundation of China (81172484) （81172484）
