南方医科大学学报Issue(4)：468-471,4.DOI:10.3969/j.issn.1673-4254.2014.04.06
SRC同源区2结构域蛋白基因多态性与慢性乙型肝炎易感性的关系
Association between CISH polymorphisms and susceptibility to chronic hepatitis B in Chinese Han population
摘要
Abstract
Objective To investigate the association between rs414171 single nucleotide polymorphisms (SNP) of cytokine-inducible src homology 2 domain protein (CISH) and the susceptibility to chronic hepatitis B. Methods A total of 233 Chinese Han patients with chronic hepatitis B and 148 age-and sex-matched healthy controls were enrolled in this case-control study. The SNP rs414171 was genotyped by Sequenom MassArray-IPLEX to analyze the relationship between rs414171 and chronic hepatitis B. Results The distribution of SNP rs414171 allele and genotype frequencies showed no significant difference between the patients and healthy controls (P>0.05). Conclusion CISH rs414171 is not significantly associated with the susceptibility to chronic hepatitis B in Chinese Han population.关键词
SRC同源区2结构域蛋白/慢性乙型肝炎/单核苷酸多态性/易感性Key words
cytokine-inducible src homology 2 domain protein/chronic hepatitis B/single nucleotide polymorphisms/susceptibility引用本文复制引用
张鑫,孙学华,周振华,李曼,高月求..SRC同源区2结构域蛋白基因多态性与慢性乙型肝炎易感性的关系[J].南方医科大学学报,2014,(4):468-471,4.基金项目
国家“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项（2012ZX10005004-002；2012ZX-10005010-002-003）；国家自然科学基金（81102570；81202662）；国家中医药管理局中医肝胆病重点学科(2010sh)；中国肝炎防治基金会王宝恩肝纤维化研究基金（CFHPC20131046）；国家教育部博士点专项基金（20123107110003）；上海市青年科技启明星计划(A类)（13QA1403500）；上海市教育委员会重点学科（第五期）建设资助项目（J50307）；上海市高校青年教师培养资助计划（szy11045）；上海市中医药事业发展三年行动计划项目（ZYSNXD-CC-ZDYJ015，ZYSNXD-CC-YJXYY）；上海市卫生局优秀青年人才培养计划（XYQ2013093）Supported by National Natural Science Foundation of China (81102570；81202662) （2010sh）
