南方医科大学学报Issue(4)：500-503,4.DOI:10.3969/j.issn.1673-4254.2014.04.13
18F-FDG PET/CT双时相显像在膀胱癌术前分期中的临床价值
Value of dual-phase 18F-FDG PET/CT in preoperative staging of bladder cancer
摘要
Abstract
Objective To investigate the clinical value of dual-phase 18F-FDG PET/CT with oral diuretics in preoperative staging of bladder cancer. Methods The imaging data were analyzed of 73 patients with bladder cancer undergoing preoperative dual-phase 18F-FDG PET/CT with oral diuretic between May, 2003 and May, 2012. All the patients underwent whole-body PET/CT scan 60 min after intravenous injection of 270-350 MBq of 18F-FDG. Additional delayed pelvic PET/CT images were acquired after forced diuresis using oral furosemide (40 mg). All the patients underwent subsequent radical cystectomy, and 18F-FDG PET/CT findings were compared with the histopathologic results to evaluate the value of dual-phase 18F-FDG PET/CT in preoperative staging. Results The concordance rate of dual-phase FDG PET/CT-based bladder cancer staging with the histopathologic results was 63.0%in the 73 patients, and was 100%(7/7) for pT4 bladder cancers. With dual-phase FDG PET/CT, the detection rate was 75.0%(6/8) for lymph node metastases, 100%(4/4) for distant metastases, and 100%(4/4) for other concurrent primary malignancies. Conclusion Though with limited accuracy in T-staging of pTa, pT1, pT2, and pT3 bladder cancer, dual-phase FDG PET/CT has important clinical value in staging of pT4 bladder cancer and in N-staging, M-staging and detection of other concurrent primary malignancies.关键词
膀胱癌/肿瘤分期/体层摄影术,发射型计算机/脱氧葡萄糖Key words
bladder cancer/staging/tomography/emission-computed, deoxyglucose引用本文复制引用
李洪生,吴湖炳,王巧愚,韩彦江,王全师..18F-FDG PET/CT双时相显像在膀胱癌术前分期中的临床价值[J].南方医科大学学报,2014,(4):500-503,4.基金项目
国家自然科学基金（81271645，81071174）；广东省医学科研基金（B2010189）Supported by National Natural Science Foundation of China (81271645,81071174) （81271645,81071174）
