南方医科大学学报Issue(4)：571-575,5.DOI:10.3969/j.issn.1673-4254.2014.04.29
生酮饮食治疗急性脊髓损伤的安全性和可行性
A clinical trial of ketogenic diet in patients with acute spinal cord injury：safety and feasibility
郭超凡 1朱青安 1周剑 1吴晓亮 1蒋晖 1鲁凯伍 1陈建庭 1吴增晖 2虞容豪 3刘捷4
作者信息
- 1. 南方医科大学南方医院脊柱骨科，广东 广州 510515
- 2. 广州军区广州总医院骨科，广东 广州510010
- 3. 广州军区广州总医院康复科，广东 广州510010
- 4. 哥伦比亚大学ICORD中心，加拿大 不列颠哥伦比亚省温哥华 V6T 1Z4
- 折叠
摘要
Abstract
Objective To conduct a clinical trial of ketogenic diet (KD) in patients with acute spinal cord injury (SCI) and evaluate its safety and feasibility by measuring blood ketone bodies and blood glucose levels. Method Ten patients with acute SCI were recruited in the trial during the period from May, 2012 to October, 2013. The patients received a standard KD after fasting for 48 h. The levels of blood ketone, blood glucose and uric ketone were tested daily, and routine blood examination, electrolytes, liver and kidney function, body mass index (BMI), sensory and motor function, and adverse reactions were monitored weekly to assess the safety and feasibility of KD. Results KD treatment lasted for a mean of 12.9 days (4 to 29 days) in these patients. In all the patients, blood ketone level increased during the fasting and maintained a level above 2.0 mmol/L after taking KD, while the uric ketone level ranged from+++to++++. The blood glucose level was in the normal range during KD. Except for blood chloride level and BMI, routine blood test results, electrolytes, liver and kidney function showed no significant changes after KD. No significant changes were observed in the sensation of light touch and pinprick. The average motor ASIA score increased from 33.3 to 35.1 after KD. Gastrointestinal dysfunction (diarrhea, nausea, poor appetite, gastric pain, and abdominal distension) was recorded in 5 patients, hypoglycemia occurred in one patient early after KD, and one patient experienced urticaria during KD. All the adverse reactions were relieved after symptomatic treatments. Conclusion This preliminary clinical trial demonstrated that KD could increase ketone bodies level and maintain a normal blood glucose level, suggesting its safety and feasibility in patients with acute SCI.关键词
生酮饮食/脊髓损伤/酮体/血糖Key words
ketogenic diet/spinal cord injury/ketone bodies/blood glucose引用本文复制引用
郭超凡,朱青安,周剑,吴晓亮,蒋晖,鲁凯伍,陈建庭,吴增晖,虞容豪,刘捷..生酮饮食治疗急性脊髓损伤的安全性和可行性[J].南方医科大学学报,2014,(4):571-575,5.
