分析化学Issue(5)：759-765,7.DOI:10.3724/SP.J.1096.2014.30988
基于碳纳米管修饰电极的脱氢酶传感器研究进展
Recent Advances in Dehydrogenase Biosensors Based on Carbon Nanotube Modified Electrodes
摘要
Abstract
Nicotinamide adenine dinucleotide ( NADH ) is involved as a cofactor in over 300 enzymatic reaction of NAD+/NADH dependent dehydrogenases. The application of amperometric NADH sensors has evolved to provide a promising measurement technique for detection of substrate or enzymatic activity. However , the direct oxidation of NADH at ordinary electrodes often requires high overpotential and suffers from low sensitivity and the fouling of the electrode surface by its oxidation products. In recent years, carbon nanotubes ( CNT) are attracting growing attention in decreasing the high overpotential for NADH oxidation and minimizing the surface fouling. This paper introduces the research progress of the NADH electrochemical sensors based on CNT-modified electrodes, and foretells its application prospect.关键词
碳纳米管/烟酰胺腺嘌呤二核苷酸/电化学检测/脱氢酶生物传感器/综述Key words
Carbon nanotube/Nicotinamide adenine dinucleotide/Electrochemical detection/Dehydrogenase biosensor/Review引用本文复制引用
李一苇,陈燕,马耀宏,史建国,王元秀,綦翠华,李秋顺..基于碳纳米管修饰电极的脱氢酶传感器研究进展[J].分析化学,2014,(5):759-765,7.基金项目
本文系科技部国家"863"计划项目(No.2012AA021201)及国家自然科学基金(No.61340032)资助 （No.2012AA021201）
