摘要
Abstract
Objectives To provide the evidence for treatment to lower respiratory tract infections, a study on distribution and drug resistance analysis of Gram-negative bacteria was conducted in the department of respiratory. Methods Sputum samples were collected from inpatients with lower respiratory tract infections in department of respiratory of our hospital from November 2010 to November 2011. Gram-negative bacteria from these samples was isolated, then the distribution and drug resistance analysis of these bacteria was conducted. Results In respiratory ward of our hospital, the main pathogenic Gram-negative bacteria were Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter baumannii, Escherichia coli, maltophilia Aeromonas, Enterobacter cloacae, etc. Of the 52 specimens were positive for Pseudomonas aeruginosa,levofloxacin, piperacillin/sulbactam resistance rates were 21.1%and 21.4%, respectively, Resistance rate to meropenem, imipenem were 38.2%, 48.9%;amikacin, cefoperazone/sulbactam, cefepime, ceftazidime, aztreonam resistance rate at 26.0%-45.0%, ampicillin, ampicillin/sulbactam, other cephalosporin resistance rates of drug testing in more than 80%.21 Acinetobacter baumannii tested for drugs showed high resistance, in addition to amikacin and piperacillin/tazobactam is relatively low, the meropenem and imipenem were 42.4%and 50.0%, ampicillin, and generation cephalosporins, second-generation cephalosporin resistance were close to 100%. Maltophilia Aeromonas levofloxacin, cotrimoxazole resistance rates were 27.3%, 14.3%, respectively, continued to show sensitivity to minocycline. Escherichia coli and Klebsiella pneumoniae ESBL s overall detection rate was 72.7%and 16.6%, respectively, of the E. coli strains producing ESBLs gentamicin, ciprofloxacin, levofloxacin, and most B amide enzymes of drug resistance rates above 90%. Different strains of Enterobacteriaceae to carbapenems, piperacillin tazobactam rate of 100%.Conclusion Gram-negative bacteria were major pathogens in the respiratory ward, They showed varying degrees of resistance to various antibiotics. To control the generation and spread of resistant strains, the rational use of antibiotics and bacterial resistance surveillance were important.关键词
下呼吸道感染/微生物学/耐药性/细菌Key words
Lower respiratory tract infection/Microbiology/Drug resistance/Bacteria
