发育医学电子杂志Issue(1)：1-5,5.
血管紧张素转化酶基因插入或缺失多态性与健康新生儿胰岛素敏感性关系的研究
Relationship between angiotensin-converting enzyme gene insertion or deletion polymorphism and insulin sensitivity in healthy newborns
韩彤妍 1崔蕴璞 1王新利 1叶鸿瑁 1朴梅花 1童笑梅 1李松1
作者信息
- 1. 北京医科大学第三医院 儿科，北京 100191
- 折叠
摘要
Abstract
Objective Our goal was to investigate the relationship between angiotensin-converting enzyme gene insertion/deletion polymorphism and the insulin sensitivity in healthy newborns. Method One hundred eighty healthy newborns, all of whom had a 1-minute Apgar score of >7 and gestational age >33 weeks, were enrolled in the study. Fasting glucose and insulin levels were measured on day 2 or 3 after birth, and angiotensin-converting enzyme genotype was determined.Result The observed frequency distribution of angiotensin-converting enzyme genotypes did not deviate from that predicted by Hardy-Weinberg equilibrium in this group. There were no statistically significant differences in birth size and shape in different angiotensin-converting enzyme genotypes. Those carriers of the genotype homozygous for the deletion allele had the highest logarithmically transformed homeostasis model assessment (HOMA) compared with those who were heterozygous or homozygous for the insertion polymorphism. When compared with those with ≥1 insertion allele, those of the genotype homozygous for the deletion allele had significantly higher logarithmically transformed fasting insulin and logarithmically transformed homeostasis model assessment results. Regarding birth weight, birth length, ponderal index, and fasting glucose concentration, there were no significant differences between the genotype homozygous for the deletion allele and the genotypes heterozygous or homozygous for the insertion allele. Conclusion In this study, the deletion allele was associated with relatively impaired insulin sensitivity in healthy neonates. It may be a clue to explain the association between the deletion allele and insulin resistance in the long-term.关键词
ACE基因I/D多态性/D等位基因/健康新生儿/胰岛素敏感性Key words
ACE gene insertion/deletion polymorphism/D allele/Healthy newborns/Insulin sensitivity引用本文复制引用
韩彤妍,崔蕴璞,王新利,叶鸿瑁,朴梅花,童笑梅,李松..血管紧张素转化酶基因插入或缺失多态性与健康新生儿胰岛素敏感性关系的研究[J].发育医学电子杂志,2014,(1):1-5,5.
