广东工业大学学报Issue(3)：122-126,5.DOI:10.3969/j.issn.1007-7162.2013.03.024
EDC／NHS 交联胶原基牙周组织引导再生膜材料的研究
Cross-linked Collagen Guided Tissue Regeneration Membrane with EDC/NHS
摘要
Abstract
A collagen GTR membrane was made with a bi-layer structure , one of whose face is loose while the other is tight .The tight face can effectively prevent the cells from growing into the defective tis-sue zone while the loose face is rough , which is helpful to cells growth and blood clot .In order to im-prove the physicochemical properties of the membranes , EDC/NHS was used as a cross-linking agent for the membranes .And the effects of cross-linking agent dosage on the physicochemical properties of mem-branes were investigated .The measurements of DSC , SEM were used to test the structure and properties of the membranes .The properties of water absorption , collagen resistance were also tested .According to the study, 0.5 mol/L EDC/NHS, cross-linking 24 h in the pH of 5.5 are the best processing conditions . Increasing further the concentration of EDC can not improve the physicochemical properties of the mem-branes .The research shows that the physicochemical properties of collagen membranes are improved sig -nificantly after being cross-linked.The denaturation temperature , anti-collagen activities are both in-creased , and the bi-layer structure is kept well .关键词
组织引导再生膜/胶原/交联/EDC/NHSKey words
GTR membrane/collagen/cross-linking/EDC/NHS分类
医药卫生引用本文复制引用
季培红,侯思润,林绣丹,任力,刘卅..EDC／NHS 交联胶原基牙周组织引导再生膜材料的研究[J].广东工业大学学报,2013,(3):122-126,5.基金项目
国家863计划项目（2011AA030105）；“十二五”国家科技支撑计划项目（2012BAI17B02）；国家自然科学基金资助项目（51273072；50803018），广东省战略新兴产业核心技术攻关项目（2012A080800015）；广东省重大科技专项资助项目 （）
