高等学校化学学报Issue(4)：766-775,10.DOI:10.7503/cjcu20130688
具有杀菌活性的2-乙氧羰基-4-芳基-1,5-苯并硫氮杂卓的初步构效关系
Preliminary Structure-activity Relationship of 2-Ethoxycarbonyl-4-aryl-1,5-benzothiazepines with Antifungal Activity
摘要
Abstract
Using 2-ethoxycarbonyl-substituted 1,5-benzothiazepines A1 and A2 as the prototy-pical structure, three series of thirty-four 1 ,5-benzothiazepine derivatives 11-17 were synthesized and evalu-ated for their an-tifungal activity against C. neoformans. The results suggested that the ethoxycarbonyl group at the position 2 of benzothiazepines A1 and A2 was essential for their antifungal activity.关键词
1 ,5-苯并硫氮杂卓/抑真菌活性/构效关系Key words
1 ,5-Benzothiazepine/Antifungal activity/Structure-activity relationship分类
化学化工引用本文复制引用
康旺,卜辉娟,李文红,李媛..具有杀菌活性的2-乙氧羰基-4-芳基-1,5-苯并硫氮杂卓的初步构效关系[J].高等学校化学学报,2014,(4):766-775,10.基金项目
国家自然科学基金(批准号:20972040)、河北省教育厅青年基金(批准号:Q2012001)和河北工业职业技术学院青年基金(批准号：Qz1102)资助.@@@@Supported by the National Natural Science Foundation of China(No.20972040), the Youth Science Foundation of Hebei Education Depart-ment of China(No. Q2012001) and the Youth Science Foundation of Hebei College of Industry and Technology, China(No. Qz1102) （批准号:20972040）
