高等学校化学学报Issue(4)：863-868,6.DOI:10.7503/cjcu20131019
新型羧甲基壳聚糖水凝胶的合成与表征
Systhesis and Characterization of Novel Carboxymethyl Chitosan Hydrogel
摘要
Abstract
Novel hydrogels were prepared by crosslinking carboxymethyl chitosan( CMCS) with 1-ethyl-3-(3-dimethyl-aminopropyl)-1-carbodiimide/N-hydroxysuccinimide ( EDC/NHS ) as catalyst at room temperature. The amount of EDC and EDC/NHS mass ratio revealed to be influencing factors on the reaction. The hydrogels exhibited typical pH-responsive character. Solid-state 13 C nuclear magnetic resonance( NMR) and differential scanning calorimetry( DSC) measurements confirmed the effective crosslinking of carboxymethyl chitosan. A minimum swelling ratio is obtained at the isoelectric point in the pH range of 3-5 . Degradation of hydrogels was carried out at 37 ℃ in phosphate buffered saline( PBS) or in PBS containing 0.2 mg/mL lysozyme. The hydrogels appeared rather stable in PBS for 10 d. The initial mass loss of 15%-45% was assigned to the dis-solution of uncrosslinked CMCS. The hydrogel with low crosslink density was degraded after 80 h in the pre-sence of lysozyme, while the hydrogel with high crosslink density was hardly degraded. A model drug, bovine serum albumin( BSA) was loaded in CMCS hydrogels. Preliminary drug release studies show that the hydrogels are promising carrier of hydrophilic drugs.关键词
羧甲基壳聚糖/水凝胶/pH响应/降解/药物释放Key words
Carboxymethyl chitosan/Hydrogel/pH Sensitivity/Degradation/Drug release分类
化学化工引用本文复制引用
朱寿进,刘法谦,王璟朝,宿烽,李速明..新型羧甲基壳聚糖水凝胶的合成与表征[J].高等学校化学学报,2014,(4):863-868,6.基金项目
国家自然科学基金(批准号:50873030,51073041)资助.@@@@Supported by the National Natural Science Foundation of China(Nos.50873030,51073041) （批准号:50873030,51073041）
