国际医药卫生导报2014，Vol.20Issue(7)：996-998,3.DOI:10.3760/cma.j.issn.1007-1245.2014.07.036
顺铂与紫杉醇不同给药方式治疗晚期卵巢癌的疗效对比分析
Comparative analysis of the efficacy of cisplatin and paclitaxel administered in different ways in the treatment of advanced ovarian cancer
摘要
Abstract
Objective To evaluate the different modes of administration of paclitaxel and cisplatin in patients with advanced ovarian cancer.Methods From June 2011 to May 2013,100 cases of advanced ovarian cancer in our hospital were randomly divided into observation group and control group,50 cases in each group.Observation group used the intravenous infusion of paclitaxel plus cisplatin intraperitoneal treatment,while control group used paclitaxel and cisplatin administered intravenously.The clinical efficacy and the incidence of adverse reactions were observed and compared between two groups.Results The effective rate in observation group was 84％,while that in control group was 56％,with statistically significant difference in short-term efficacy between two groups (P ＜ 0.05).The incidence of leukopenia had no statistically significant difference between two groups (P ＜ 0.05).The incidences of nausea and vomiting,hair loss,kidney damage,muscle and joint pain in observation group were significantly lower than those in control group,with statistically significant differences (P ＜ 0.05).Conclusion Intravenous administration of paclitaxel plus cisplatin intraperitoneal treatment of advanced ovarian cancer has good efficacy,with fewer adverse reactions,which should be promoted in clinical practice.关键词
紫杉醇/顺铂/卵巢癌/疗效Key words
Paclitaxel/ Cisplatin/ Ovarian cancer/ Efficacy引用本文复制引用
吴超扬,郑崇广,马志红..顺铂与紫杉醇不同给药方式治疗晚期卵巢癌的疗效对比分析[J].国际医药卫生导报,2014,20(7):996-998,3.
