硅酸盐学报Issue(4)：464-470,7.DOI:10.7521/j.issn.0454-5648.2014.04.08
HAp/mSiO2载药颗粒的制备及体外药物释放行为
Synthesis and in Vitro Release Behavior of Core-Shell Structured Hydroxyapatite/Mesoporous Silica Powders with Drug Storage
摘要
Abstract
Nano-sized spherical hydroxyapatite (HAp)particles were prepared via a wet chemical precipitation method after the solutions comprising calcium and phosphate precursors were mixed at a slow addition rate.According to the high adsorption ca-pacity for drug (methylene blue,MB)and the standard deviation,the optimal experimental condition of sol-gel route was deter-mined via the orthogonal experiment design method.The HAp/mesoporous silica (HAp/mSiO2 )powder was fabricated through the deposition of mSiO2 on HAp at low silanophilic activity under the optimal experimental condition.The adsorption capacity of MB onto HAp/mSiO2 in solutions containing MB at a concentration of 0.10 g/L is 79.26 mg/g.The adsorption iso-therm of methylene blue onto HAp/mSiO2 is a type II isotherm,i.e.,the monomer and dimmers of drug molecules are ad-sorbed on HAp/mSiO2 .The sustained-release behavior of drugs from HAp/mSiO2 is related to the pH value of the buffers (pH=7.2~7.4 in phosphate buffered saline and pH=4.7 in lysosome-like buffers)due to the influence of solution properties on the microstructures of drug carriers and interaction mechanisms between drug molecules and powders.关键词
羟基磷灰石/介孔二氧化硅/核壳结构/药物载体/释放行为Key words
hydroxyapatite/mesoporous silica/core-shell structured/drug carrier/release behavior引用本文复制引用
李成峰,高天宇,贺立群,陆昊,葛筱璐..HAp/mSiO2载药颗粒的制备及体外药物释放行为[J].硅酸盐学报,2014,(4):464-470,7.基金项目
山东理工大学博士基金(406017)项目资助 （406017）
山东省高等学校科技计划项目(J11LD52) （J11LD52）
山东省自然科学基金(ZR2013EML008)项目资助。 （ZR2013EML008）
