中国妇幼健康研究Issue(4)：487-489,3.DOI:10.3969/j.issn.1673-5293.2013.04.011
硫柳汞对早产大鼠前额叶5-HT2 AR 和 DRD4表达的研究
The influence of thiomersal on 5-HT2AR and DRD4 in prefrontal cortex of premature rat
摘要
Abstract
Objective To discover the influence of thiomersal on serotonin 2A receptor(5-HT2AR)and the dopamine D4 receptor (DRD4) in prefrontal cortex(PFC)of premature rat.Methods Thimerosal of standard dose(12.5μg/dose) in vaccines and 2, 3, 4 times standard dose(32.80μg/kg, 65.60μg/kg, 98.4μg/kg and 131.20μg/kg converted according to surface conversation method ) were injected to sprague dawley premature rats delivered at 20th day of gestation at the first day .As control, the 5th group received saline injections at the same time .The western blot was used to evaluate the expression of 5-HT2AR and DRD4 in PFC on the postnatal 49th day. Results The expression of 5-HT2AR and DRD4 was significantly different among five groups (F=27.089,P<0.01;F=91.034,P<0.01).Compared with the saline group,the expression of 5-HT2AR and DRD4 decreased in 131.20μg/kg group(q=7.824, P<0.01;q=8.311, P<0.01).No significant difference was found among other groups .Conclusion The expression of 5-HT2AR and DRD4 in PFC decline when exposed on high dose of thimerosal , which indicates that vaccinating vaccines with thiomersal should not be given continuously or in short time .关键词
硫柳汞/早产/5羟色胺受体/2A多巴胺受体D4Key words
thimerosal/preterm/serotonin 2A receptor(5-HT2AR)/dopamine D4 receptor(DRD4)分类
医药卫生引用本文复制引用
贺莉,张婕,邵冬冬,黄燕霞,陈艳妮..硫柳汞对早产大鼠前额叶5-HT2 AR 和 DRD4表达的研究[J].中国妇幼健康研究,2013,(4):487-489,3.基金项目
陕西省自然科学基金资助项目 （）
