摘要
Abstract
Objective To study the curative effect of small dose of erythromycin and non-nutritive sucking for premature infants with feeding intolerance .Methods Totally 120 cases of premature infants with feeding intolerance were selected , and they were randomly divided into treatment group 1(n1 =40), treatment group 2(n2 =40) and control group(n=40).All of the three groups were given comprehensive treatment .On the basis of the comprehensive treatment , the treatment group 1 was given a small dose of erythromycin 1-3mg· kg-1 · d-1 in 5%glucose solution.It was given by micro pump infusion , 1 time/d, 7d.The treatment group 2 was provided with non-nutritive sucking based on comprehensive treatment and small dose of erythromycin treatment . The control group was given comprehensive treatment only .The gastric retention disappear time , abdominal distention disappearance time , the time birth weight recovery, daily weight gain, all oral feeding time and the length of stay of three groups were observed .Liver function was monitored before and after medication , and the frequency of stool and crying were observed during medication .Results Compared with the control group , the gastric retention disappear time (3.92 ±1.05/3.16 ±0.92), abdominal distention disappearance time (3.65 ±0.82/3.08 ±0.95), the time birth weight recovery(9.51 ±2.12/8.12 ±2.61), all oral feeding time(17.91 ±8.13/14.62 ±6.22) and hospitalization stay (23.82 ±8.13/20.73 ±5.34)in the treatment group 1 and group 2 were shorter, and the differences were statistically significant (t value was 2.23/6.19, 4.31/5.47, 5.28/7.29, 2.01/4.54 and 4.07/6.64, respectively, all P<0.05).The daily weight gain was more in treatment group 1 and group 2 than in the control group, and the difference was significant(t=2.00/3.76,P<0.05).In the treatment group 2 the gastric retention disappear time , abdominal distention disappearance time , the time birth weight recover , all oral feeding time and hospitalization stay were shorter than in treatment group 1, and there were significant differences (t value was 2.92, 2.29, 2.69, 2.05 and 2.43, respectively, all P<0.05).However, there was no significant difference in daily weight gain (P>0.05).Conclusion Application of small dose of erythromycin and non-nutritive sucking on feeding intolerance in preterm infants can promote gastrointestinal motility with synergistic action .关键词
小剂量红霉素/非营养性吸吮/早产儿/喂养不耐受Key words
small dose of erythromycin/non-nutritive sucking/premature/feeding intolerance分类
医药卫生
