中国妇幼健康研究Issue(5)：655-657,671,4.DOI:10.3969/j.issn.1673-5293.2013.05.010
反复发生妊娠丢失的1949对夫妇染色体核型分析
A cytogenetic analysis of recurrent fetal wastage in 1 949 couples
程琛 1王楠 1邓东锐 1左伟 1彭琳 1党静 1周媛 1蒋敏 1何梦舟 1凌霞珍1
作者信息
- 1. 华中科技大学同济医学院附属同济医院妇产科，湖北武汉 430030
- 折叠
摘要
Abstract
Objective To investigate the frequency of chromosomal abnormalities in couples with recurrent fetal wastage ( RFW) and assess the relevance between genetic factors and RFW , and to explore the importance of genetic factors in RFW .Methods From 1994 to 2010 the cytogenetic study was conducted in 1 949 couples (3 898 patients) who had RFW.Their peripheral blood lymphocytes were cultured . Chromosome karyotype analysis was conducted .Results Of 1 949 couples, chromosomal abnormalities were found in 113(5.80%,113/1 949) cases, including 10 (0.51%) cases of numerical chromosomal abnormalities and 103 (5.28%) cases of structural abnormalities . Of the cases of structural abnormalities , 53 cases were found with reciprocal translocations , 20 with robertsonian translocation , 24 with inversions, 5 with chromosomal deletion and 1 with isochromosome.Polymorphisms of heterochromatin were found in 73 cases, with the detection rate of 3.75%(73/1 949).Conclusion Chromosomal abnormality is closely related with RFW .Chromosome analysis for genetic counseling is helpful in finding causes and in providing scientific basis for antenatal diagnosis and good birth .关键词
反复妊娠丢失/细胞遗传学/染色体异常/临床价值Key words
recurrent fetal wastage ( RFW)/cytogenetics/chromosome abnormalities/clinical value分类
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程琛,王楠,邓东锐,左伟,彭琳,党静,周媛,蒋敏,何梦舟,凌霞珍..反复发生妊娠丢失的1949对夫妇染色体核型分析[J].中国妇幼健康研究,2013,(5):655-657,671,4.
