中国妇幼健康研究Issue(6)：822-823,826,3.DOI:10.3969/j.issn.1673-5293.2013.06.011
p57和 p53在葡萄胎和水肿性流产中的表达及意义
Expressions and significance of p57 and p53 in hydatidiform mole and hydropic abortuses
赵可 1钱建忠 1徐洪明1
作者信息
- 1. 东南大学医学院附属江阴医院病理科，江苏江阴 214400
- 折叠
摘要
Abstract
Objective To investigate the expressions of p57 and p53 in complete hydatidiform mole (CHM), partial hydatidiform mole (PHM) and hydropic abortuses (HA) and their significance.Methods Immunohistochemical staining (EnVision method) was performed to detect the expression of p57 and p53 in 25 cases of CHM, 21 cases of PHM and 20 cases of HA.Results The positive rate of p57 in CHM, PHM and HA was 4.0%, 90.5%and 95.0%, respectively.The expression of p57 was significantly lower in CHM than in PHM and HA (χ2 value was 34.730 and 37.265, respectively, both P<0.01).There was no significant difference between PHM and HA (P>0.05).The positive rate of p53 in CHM, PHM and HA was 84.0%, 61.9% and 15.0%, respectively.The expression of p53 was significantly lower in HA than in PHM and CHM (χ2 value was 9.471 and 21.254, respectively, both P<0.01).There was no significant difference between PHM and CHM (P>0.05).Conclusion P57 can be considered as a useful index in differential diagnosis of CHM from PHM and HA.P53 may be helpful in distinguishing HA from PHM when p 53 is expressed.关键词
葡萄胎/水肿性流产/免疫组织化学/周期素依赖激酶抑制剂p57/肿瘤抑制蛋白质p53Key words
hydatidiform mole ( HM)/hydropic abortuses ( HA)/immunohistochemistry/p57/p53分类
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赵可,钱建忠,徐洪明..p57和 p53在葡萄胎和水肿性流产中的表达及意义[J].中国妇幼健康研究,2013,(6):822-823,826,3.
