国际生殖健康计划生育杂志Issue(5)：361-364,4.
性发育异常发病机制的研究进展
Research Progress of Pathogenesis of Disorders of Sex Development
王春庆(综述) 1田秦杰(审校)1
作者信息
- 1. 100730 北京，中国医学科学院 北京协和医学院北京协和医院妇产科
- 折叠
摘要
Abstract
Normal sex differentiation includes the formation of primordial gonads, sex determination and ovarian or testis development. The misregulation of gene expression in each process may lead to the disorders of sex development (DSD). DSD is defined by congenital conditions of the atypical chromosome,gonadal or anatomical sex. With the development of molecular biotechnology,more and more genes and signaling pathways are discovered to be involved in sex differentiation and development. For example,some genes such as SRY、SF1、W T1 and Sox9 are closely related to testicular development, while others such as Wnt/Rspo1/B-catenin pathway and genes like Dax1、Foxl2 play an important role in ovarian differentiation. Some none-coding RNA and transforming growth factor also regulate the sexual differentiation. The developments of both testis and ovary are active, and transverse differentiation can appear according to some abnormal genes even after birth.关键词
睾丸/卵巢/性腺发育不全/Y染色体/性决定(分析)/微RNAs/信号传导Key words
Testis/Ovary/Gonadal dysgenesis/Y chromosome/Sex determination (analysis)/MicroRNAs/Signal transduction引用本文复制引用
王春庆(综述),田秦杰(审校)..性发育异常发病机制的研究进展[J].国际生殖健康计划生育杂志,2013,(5):361-364,4.
