国际病理科学与临床杂志Issue(4)：327-331,5.DOI:10.3969/j.issn.1673-2588.2013.04.011
成纤维生长因子受体信号通路与横纹肌肉瘤上皮间叶转化
Signaling pathway of fibroblast growth factor receptor and epithelial-mesenchymal transition in rhabdomyosarcoma
摘要
Abstract
Rabdomyosarcoma (RMS), common in the children and adolescence, is a mesenchymal malignancy derived from skeletal muscle. RMS can be classiifed into 3 main subtypes, more aggressive alveolar rhabdomyosarcoma (ARMS), more common, and better outcome embryonal rhabdomyosarcoma (ERMS) and the rare pleomorphic rhabdomyosarcoma (PRMS). The molecular mechanism for RMS is still unclear due to the different types of RMS with differences in histologic characteristic, age of onset, location, and prognosis. Recent studies are mainly focused on the key genes and signaling pathways in RMS. It has been found that ifbroblast growth factor receptor (FGFR) signaling pathway is strongly associated with the proliferation and metastasis of RMS. More interestingly, it has been conifrmed that epithelial-mesenchymal transition (EMT) promotes the proliferation and metastasis in lots of epithelial tumors. So we hypothesize that EMT promotes proliferation and metastasis via FGFR signaling pathway in RMS. In this article we tried to understand the development of RMS via EMT and FGFR signaling pathway. Hopefully, it can offer a new view for the treatment and prognosis assessment of RMS.关键词
横纹肌肉瘤/成纤维生长因子受体/上皮间叶转化Key words
rhabdomyosarcoma/ifbroblast growth factor receptor/epithelial-mesenchymal transition引用本文复制引用
李晓营,刘春霞,李锋(综述)..成纤维生长因子受体信号通路与横纹肌肉瘤上皮间叶转化[J].国际病理科学与临床杂志,2013,(4):327-331,5.基金项目
国家自然科学基金（81160322）。This work was supported by the National Natural Science Foundation of China (81160322) （81160322）
