神经损伤与功能重建Issue(6)：426-430,5.DOI:10.3870/sjsscj.2013.06.010
不同时程的慢性不可预计温和应激对大鼠海马神经可塑性相关蛋白水平的影响
Effects of Chronic Unpredictable Mild Stress with Different Time Courses on Neuroplasticity-related Proteins Expression in Rat Hippocampus
摘要
Abstract
Objective:To explore the effect of different time courses of chronic unpredictable mild stress on neu-roplasticity-related proteins expression in the adult rat hippocampus. Methods:Twenty-four rats were randomly divided into four groups with 6 rats in each group:the control group, rats without stress;M1 group in which rats were subjected to CUMS for 1 week; M2 group, in which rats were subjected to CUMS for 2 weeks; and M3 group in which rats were subjected to CUMS for 3 weeks. The levels of brain-derived neurotrophic factor (BD-NF), cAMP response element binding protein (CREB), B-cell lymphoma-2 (Bcl-2) protein in the hippocampus were detected using Weston blot. Results:when compared to the expression of BDNF, CREB, and Bcl-2 proteins in the controlled group, those in the M1 and M3 groups were significantly decreased ( <0.05), and there was no different changes in those protein in the M2 group. The amounts of BDNF, CREB, and Bcl-2 protein showed no significant difference between the M1 group and M3 group. Conclusion:Different time courses of CUMS might affect the expression of proteins implicated in neuroplasticity, providing insight into the role of neuroplasticity-related proteins in the depression.关键词
慢性不可预计温和应激/时程/海马/脑源性神经营养因子/cAMP反应元件结合蛋白/B淋巴细胞瘤-2Key words
chronic mild stress/neuroplasticity-related proteins/rat/hippocampus/brain-derived neurotrophic factor/cAMP response element binding protein/B-cell lymphoma-2分类
医药卫生引用本文复制引用
肖玲,舒畅,唐记华,王晓萍,王高华..不同时程的慢性不可预计温和应激对大鼠海马神经可塑性相关蛋白水平的影响[J].神经损伤与功能重建,2013,(6):426-430,5.基金项目
国家自然科学基金青年基金 （）
