神经损伤与功能重建Issue(1)：16-19,4.DOI:10.3870/sjsscj.2014.01.004
激光散斑成像监测C57小鼠皮质血流及光化学缺血变化
Laser Speckle Imaging of Mice Cerebral Blood Flow and Cortical Infarction
摘要
Abstract
ObjectiveTo explore the application of laser speckle imaging in monitoring C57BL/6 mice cerebral blood flow under normal condition and the photochemical infarction. Methods:Eight 8~10 weeks male C57BL/6 mice were used for blood flow detection. The cortex blood flow of the C57BL/6 mice was monitored by laser speckle imaging system for 30 minutes. Five 8~10 weeks male C57BL/6 mice were induced cortical photochemi-cal infarct while five 8~10 weeks male C57BL/6 mice in sham group received sham operation. Laser speckle imaging was preformed before and 24 hs after the surgery. Results:Eight C57 mice can be detected cerebral blood flow imaging with high image quality without damaging the skull. The small blood vessels can be observed by this system. In the photothrombosis group, small blood flow was decreased or disappeared on the cortex of mice using laser speckle image. Conclusion:The image of C57 mice brain cortical blood flow could be obtained by laser speckle imaging with high spatial and temporal resolution.关键词
激光散斑成像/脑梗死/脑血流Key words
laser speckle imaging/ischemic stroke/cerebral blood flow分类
医药卫生引用本文复制引用
方瑜,邱占东,闵哲,熊永洁,胡文涛,黄梁江,张苏明..激光散斑成像监测C57小鼠皮质血流及光化学缺血变化[J].神经损伤与功能重建,2014,(1):16-19,4.基金项目
武汉市科技计划项目 （）
