神经损伤与功能重建Issue(2)：111-114,4.DOI:10.3870/sjsscj.2014.02.007
环氧合酶-2基因-1195 G>A多态性位点与缺血性脑卒中患者阿司匹林抵抗的相关性
Correlation between Single Nucleotide Polymorphism of -1195G>A of COX-2 Gene and Aspirin Resistance in Patients with Ischemic Stroke
陈忠云 1李珊珊 1李婧 1徐志伟 1杨旭1
作者信息
- 1. 航天中心医院 北京大学航天临床医学院 神经内科北京 100049
- 折叠
摘要
Abstract
ObjectiveTo study the correlation between single nucleotide polymorphisms (SNPs) of-1195G>A of cyclooxygenase-2 (COX-2) gene and Aspirin resistance (AR) in patients with ischemic stroke (IS). Methods:According to the rate of platelet aggregation, 210 northern Chinese Han patients with IS were divided into Aspirin sensitivity (AS) group (147 cases) and non-Asgroup [17 AR cases, and 46 Aspirin semi-resistance (ASR) cases] (n=63). The SNPs were detected by Amplification mutation system (ARMS) combined with TaqMan probe in a real-time PCR. Results:There were no significant differences in the genotype, allele, additive or recessive model frequencies of-1195G>A polymorphisms between the 2 groups. The significant difference between (GA+AA) and GG genotype frequencies of-1195G>A polymorphisms were observed in groups of AS and non-AS ( =0.03). For A allele of-1195G>A, there was also a significant difference between the two groups ( =0.02). On multivariate analysis controlling for conventional vascular risk factors, the-1195 GA and AA genotypes were identified inde-pendently to be related with (ASR+AR) ( =2.41,:1.07~5.42, =0.03). Conclusion:-1195G>A poly-morphism of COX-2 gene was associated with AR or ASR in patients with IS, which may be a genetic predisposi-tion to phenotypes of AR or ASR.关键词
环氧合酶-2/缺血性脑卒中/阿司匹林抵抗Key words
cyclooxygenase-2/ischemic stroke/Aspirin resistance分类
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陈忠云,李珊珊,李婧,徐志伟,杨旭..环氧合酶-2基因-1195 G>A多态性位点与缺血性脑卒中患者阿司匹林抵抗的相关性[J].神经损伤与功能重建,2014,(2):111-114,4.
