摘要
Abstract
Objective To observe the clinical efficacy of ulinastatin on the treatment of severe acute pancreatitis , and to investigate its influence on the serum levels of inflammatory cytokines .Methods Sixty cases of severe acute pancreatitis were randomly divided into two groups according to random number table ,30 cases in the control group received basic treatment and 30 cases in the observation group were treated with basic treatment and intravenous infusion of ulinastatin(100 000 U/d) for 7 days.The patients were evaluated by APACHEⅡ in two groups before and after treatment as well as mean artery pressure (MAP),heart rate(HR),procalcitonin(PCT),C-reactive protein(CRP), creatinine(Cr),and the serum levels of interleukin (IL)-6,IL-8,IL-10,tumor necrosis factor(TNF)-ɑwere detected. Results The APACHEⅡscores of observation group on the 1st,3rd,5th,7th day after treatment were significantly lower than those of control group (P<0.05).The MAP of observation group on the 1st,7th day after treatment were significantly higher than those of control group (P<0.05) while HR,PCT,CRP and Cr were significantly lower than those of control group(P<0.05).The serum level of IL-10 of observation group was significantly higher than that of control group(P<0.05),but the serum levels of IL-6,IL-8,TNF-ɑwere significantly lower than those of control group (P<0.05).Conclusion The treatment combined with ulinastatin for SAP could effectively regulate the serum level of the patients′inflammatory cytokines and improve the clinical efficacy .关键词
重症胰腺炎/乌司他丁/炎症因子Key words
Severe pancreatitis/Ulinastatin/Inflammatory cytokine分类
医药卫生
