广西医学Issue(1)：13-15,3.DOI:10.11675/j.issn.0253-4304.2014.01.05
细胞周期增殖指标在甲状腺乳头状癌中的诊断价值
Value of Proliferation Biomarkers of Cell Cycle in Diagnosis of Papillary Thyroid Carcinoma
摘要
Abstract
Objective To explore the value of minichromosome maintenance protein 7 ( MCM7 ) and Ki-67 proteins in the proliferation biomarkers of cell cycle in the diagnosis of papillary thyroid carcinoma .Methods Immu-nohistochemical SP method was used to detect the expressions of MCM 7 and Ki-67 proteins in 40 cases of papillary thyroid carcinoma,30 cases of thyroid adenoma ,30 cases of nodular goiter and 20 cases of normal thyroid tissue . Results The positive rates of MCM7 and Ki-67 expressions in papillary thyroid carcinoma were 100.00%(40/40) and 80.00%(32/40),respectively,which were significantly higher than those in thyroid adenoma ,nodular goiter and normal thyroid tissue(all P<0.01).In papillary thyroid carcinoma ,the positive rate of MCM7 expression was significantly higher than that of Ki-67 expression(P<0.01).The expressions of MCM7 and Ki-67 proteins in papillary thyroid carcinoma were not related with patients′gender,age,tumor diameter and lymph node metastasis (all P>0.05).The expression of MCM7 protein had a positive correlation with the expression of Ki-67 protein in papillary thyroid carcinoma tissue (r=0.551,P<0.05).Conclusion The high expressions of MCM7 and Ki-67 protein in the thyroid of patients with cell cycle disorder and abnormal cell proliferation may involve in the development of papillary thyroid carcinoma .The combined examination of MCM 7 and Ki-67 proteins may be used as a biomarker in the diagnosis of papillary thyroid carcinoma.MCM7 is superior to Ki-67 in evaluating the activity of cell proliferation of malignant thyroid tumor ,and it has certain significance on evaluating the proliferation of tumor cells .关键词
甲状腺乳头状癌/微小染色体维持蛋白7/Ki-67蛋白/免疫组织化学Key words
Papillary thyroid carcinoma/Minichromosome maintenance protein/Ki-67 protein/Immunohistochemistry分类
医药卫生引用本文复制引用
史琳,张安文,赵时梅,罗宇,任传伟,马新博,杨燕初..细胞周期增殖指标在甲状腺乳头状癌中的诊断价值[J].广西医学,2014,(1):13-15,3.基金项目
广西教育厅科研项目 （）
