广西医学Issue(2)：170-172,3.DOI:10.11675/j.issn.0253-4304.2014.02.09
检测（1，3）-β-D-葡聚糖在老年肺癌侵袭性肺部真菌感染中的临床价值
Clinical Value of Plasma (1,3)-β-D-Glucan Detection for Invasive Fungal Infections in Aged Patients with Lung Cancer
摘要
Abstract
Objective To analyze the clinical value of the detection of plasma (1,3)-β-D-glucan (BG) for invasive fungal infection ( IPFI ) in aged patients with lung cancer .Methods Sixty-five aged lung cancer patients with infection were divided into 3 groups according to the diagnostic result ,20 cases of IPFI(group A),22 cases of pulmonary mixed infection(fungi +bacteria,group B) and 23 cases of pulmonary bacterial infection (group C).In addition,20 healthy people were enrolled in this study ( group D ) .The blood was drew from all patients 1,3 days after they were admitted to hospital,and 3,7,10,14,17,21,24 days from the patients in group A and group B after antifungal therapy , and once only from the patients in group D .The concentration of plasma BG was detected among patients in each group.Results Candida Albicans was cultured in 26 patients in group A and group B,which accounted for 61.91%. The concentration of plasma BG in group A and group B was significantly higher than that in group C and group D ( P<0 .01 ) .In the patients of group A and group B , the sensitivity and negative predictive value of consecutive BG positive decreased ,but the specificity increased compared with those of single BG positive ,and the positive predictive value of consecutive BG positive of patients in group B increased in contrast with that of single BG positive .The concentrations of plasma BG in patients 10 ,14 ,17 ,21 and 24 days after treatment significantly reduced in contrast with those before treatment in group A(P<0.05).The concentrations of BG in plasma of patients 14,17,21 and 24 days after treatment significantly reduced in contrast with those before treatment in group B (P<0.01).Conclusion The (1,3)-β-D-glucan test is a valuable method for diagnosing IPFI at early stage rapidly as well as monitoring the efficacy dynamically in aged patients with lung cancer .关键词
肺癌/肺部真菌感染/(1, 3)-β-D-葡聚糖/老年人Key words
Lung cancer/Invasive pulmonary fungal infection/(1,3)-β-D-glucan/Aged patient分类
医药卫生引用本文复制引用
汤小军,黄建春,刘航,陈杏春,雷志坚,龙胜泽..检测（1，3）-β-D-葡聚糖在老年肺癌侵袭性肺部真菌感染中的临床价值[J].广西医学,2014,(2):170-172,3.基金项目
广西自然科学基金资助项目 （）
