广西医学Issue(3)：277-280,4.DOI:10.11675/j.issn.0253-4304.2014.03.02
VEGF-1154 G／A基因多态性与EB 病毒在鼻咽癌发生中的交互作用研究
Interaction between VEGF-1154 G/A Gene Polymorphism and EB Virus in Nasopharyngeal Carcinoma
摘要
Abstract
Objective To explore the association of development of nasopharyngeal carcinoma in Guangxi population with VEGF-1154G/A gene polymorphism and EB virus .Methods One hundred and ninety-seven patients with nasopharyngeal carcinoma were in the case group ,197 healthy people in the control group .A case-control study was applied to analyzing the association of development of nasopharyngeal carcinoma with VEGF -1154G/A gene polymorphisms and EB virus . Results The distributions of VEGF-1154 GG(40.0%) and GA+AA(60.0%) in the case group differed from those (55.8%,44.2%) in healthy controls(P<0.05).Compared with the control (26.9%),the frequency of A allele in the case group(40.4%) was significantly higher (P<0.05).The genotype G/A or A/A containing A allele in contrast to genotype G/G increased the risk of nasopharyngeal carcinoma (P<0.05).However,there were no interactions among VEGF-1154 A allele ,EB-VCA-IgA and family history of cancer in the process of occurrence of nasopharyngeal carcinoma (P>0.05).Conclusion VEGF-1154 A allele is a risk factor of nasopharyngeal carcinoma ,but there are no interactions among VEGF-1154 A allele,EB-VCA-IgA and family history of cancer in the process of occurrence of nasopharyngeal carcinoma .关键词
鼻咽癌/血管内皮生长因子/单核苷酸多态性/EB病毒Key words
Nasopharyngeal carcinoma/Vascular endothelial growth factor/Single nucleotide polymorphism/EB virus分类
医药卫生引用本文复制引用
程小伟,姜力,陈静珊,张勇..VEGF-1154 G／A基因多态性与EB 病毒在鼻咽癌发生中的交互作用研究[J].广西医学,2014,(3):277-280,4.基金项目
广西自然科学基金资助项目 （）
