摘要
Abstract
Objective To investigate the influences of rosuvastatin on serum inflammatory factors ,blood lipid level and carotid plaque in patients with acute coronary syndrome ( ACS) .Methods Ninety-eight cases of ACS were randomly divided into two groups ,49 cases in the control group were treated with conventional ACS therapy ,while 49 cases in the research group took rosuvastatin (10 mg per day before bedtime ,6 months) besides conventional therapy . The serum inflammatory factors and blood lipid level were detected before and after treatment in both groups ,and the changes of carotid plaque were observed .Results The levels of tumor necrosis factor α(TNF-α),interleukin 6(IL-6) and matrix metalloproteinase 9 ( MMP-9 ) after treatment were significantly lower than those before treatment in both groups,but the decrease in the research group was more significant (P<0.05).The carotid plaques size,number, thickness and intima-media thickness ( IMT) after treatment were significantly lower than those before treatment in the research group (P<0.05).In the control group,the carotid plaques size,number,thickness and intima-media thickness (IMT) after treatment improved compared with those before treatment,which showed no statistical significance(P>0.05). Conclusion Rosuvastatin can improve blood lipid and plaques inflammation in ASC patients ,with anti-inflammatory effect.It can make atheromatous plaque stable .关键词
急性冠脉综合征/瑞舒伐他汀/炎性介质/血脂/颈动脉斑块Key words
Acute coronary syndrome/Rosuvastatin/Inflammatory factor/Blood lipid/Carotid plaque分类
医药卫生
