摘要
Abstract
Objective:To analyze the clinical significance of determining plasma D-dimer ( DD) and fibrinogen degradation products ( FDP) in patients with acute cerebral infarction.Methods: A total of 93 patients with acute cerebral infarction ( acute cerebral infarction group ) were collected fasting venous blood 24 hours, 3 days and 7 days after admitted in hospital, and ELISA and Clause assay were used to determine DD and FDP levels.45 healthy examines were selected as controls (control group).Results:The DD level at 24 hours and 3 days of acute cerebral infarction group was statistically higher than that of control group ( P<0.01, P<0.05), but the DD level at 7 days had no statistical difference compared with the control group ( P>0.05).The FDP level at 24 hours of acute cerebral infarction group showed no difference compared with control group (P>0.05), but the FDP level at 3 days and 7 days was significantly higher than that of control group (P<0.01, P<0.05).The DD and FDP levels of moderate and severe group were obviously higher than those of mild group (P<0.05, P<0.01), and the DD and FDP levels of severe group were higher than those of moderate group ( P<0 .05 ) .The DD FDP levels of median and large size infarct were statistically higher than those of small size infarct (P<0.05, P<0.01), and the DD FDP levels of large size infarct were obviously higher than those of median size infarct ( P<0 .05 ) .The DD level of acute cerebral infarction was positively correlated with FDP level (r=0.71, P<0.05).Conclusion:The plasma DD and FDP level of pa-tients with acute cerebral infarction are increased at different degrees, monitoring the plasma DD and FDP level is important for judging the severity of cerebral infarction and size of infarct.关键词
急性脑梗死/D-二聚体/纤维蛋白原降解产物Key words
Acute cerebral infarction/D-dimer/Fibrinogen degradation products
