郑州大学学报（医学版）Issue(4)：499-502,4.DOI:10.3969/j.issn.1671-6825.2013.04.018
饮食干预对高脂高糖诱导的妊娠期大鼠胰岛素抵抗状态的影响
Effect of dietary intervention on pregnant rats'insulin resistance induced by highfat and sugar diet
摘要
Abstract
Aim:To evaluate the effect of dietary interventions on insulin resistance ( IR) in pregnant rats .Methods:A total of 40 female SD rats were divided into four groups:SFP group, GHP group, NP group and NC group , 10 in each group.SFP and GHP groups were given high sucrose and fat diet ,NP and NC groups were given normal diet .Six weeks lat-er,the female rats of SFP,GHP and NP groups were put into the same cage with the male rats to conceive .At the 20th day, the weight were detected, and the weight gain were calculated, the levels of fast insulin (Fins),fast glucose(FBG),and blood lipids were detected , and hyperinsulinemic-euglycemic clamp test was performed to detect glucose infusion rate ( GIR) .Results:The weight gain ,the levels of Fins and FBG ,and GIR among the 4 groups had differences ( F=44 .379 , 631.570,1 494.300 and 457.430,P<0.001).Compared with those of the NP group , the levels of Fins and FBG of SFP group were higher, and that of GIR was lower(P<0.05).Compared with those of the SFP group, the levels of Fins and FBG of GHP group were lower, and that of GIR was higher (P<0.05).Conclusion: Dietary intervention could signifi-cantly improve the state of IR in pregnant rats with high fat and sugar diet .关键词
妊娠/胰岛素抵抗/大鼠/饮食干预Key words
pregnancy/insulin resistance/rat/dietary intervention分类
医药卫生引用本文复制引用
李变锋,付艳芹,张东铭,张苏河..饮食干预对高脂高糖诱导的妊娠期大鼠胰岛素抵抗状态的影响[J].郑州大学学报（医学版）,2013,(4):499-502,4.基金项目
河南省医学科技攻关计划重点基金资助项目201002010 （）
