郑州大学学报（医学版）Issue(4)：520-523,4.DOI:10.3969/j.issn.1671-6825.2013.04.025
甲状腺功能状态对大鼠微种植体支抗即刻负载稳定性的影响
Stability of micro-implant instant load in rats with different thyroid func-tional status
摘要
Abstract
Aim:To observe the stability and the feasibility of micro-implant instant load on rats with different thyroid functional status .Methods: Thirty healthy female adult Wistar rats were allocated into 3 groups randomly , 10 in each group.The hyperthyroid group was given euthyrox , the hypothyroidism group was given 0.1%propylthiouracil ,and the nor-mal group was given distilled water(all gavaged 0.01 mL/g weight every day).After 28 days, micro-implants were implan-ted and then loaded 0.98 N force instantly, and the animals were sacrificed after 30 days.The separation distance of micro-implants in the bone was measured by X-ray and fluorescence microscopy was used to observe hard tissue slice including the implant.Finally, the bone mineralization deposition rate and bone combining rate were calculated .Results: Among the three groups , the differences in the separation distance , bone combining rate and the bone mineralization deposition rate of the micro-implants were statistically significant (F=11.825,39.953 and 20.045,P<0.05).Hyperthyroid group had the highest bone mineralization deposition rate , bone combining rate ,and the separation distance of the micro-implants than the other 2 groups, and these parameters were the lowest in the hypothyroidism group (P<0.05).Conclusion:Micro-implant instant load is feasible under different thyroid functional status; thyroid hormones have influence on the stability of micro-implants, and the bone combining rate is the highest under hyperthyroid and it is the lowest under hypothyroidism .关键词
甲状腺素/即刻负载/微种植体支抗/骨结合率/稳定性/大鼠Key words
thyroid hormone/instant load/micro-implant/bone combining rate/stability/rat分类
医药卫生引用本文复制引用
张彬,李欣,李金源,王旭明,孟菲,李儒..甲状腺功能状态对大鼠微种植体支抗即刻负载稳定性的影响[J].郑州大学学报（医学版）,2013,(4):520-523,4.基金项目
唐山市科技支撑项目08130219 C （）
