郑州大学学报（医学版）Issue(4)：536-539,4.DOI:10.3969/j.issn.1671-6825.2013.04.030
ω-3多不饱和脂肪酸和谷氨酰胺对具有营养风险的晚期肺癌化疗患者的影响
Efficacy of combination of ω-3 polyunsaturated fatty acids and glutamine with chemotherapy on patients with advanced primary lung cancer and high nutritional risk
韩东景 1赵楠 1薛永飞 2沈艳丽 2马慧利 2张蕾2
作者信息
- 1. 南阳市中心医院营养科南阳473001
- 2. 南阳市中心医院肿瘤科南阳473001
- 折叠
摘要
Abstract
Aim:To explore the efficacy of the combination of ω-3 polyunsaturated fatty acids ( PUFA) and glutamine ( Gln) with chemotherapy on patients with advanced primary lung cancer and high nutritional risk .Methods:A total of 135 patients with advanced lung cancer and NRS 2002 score ≥3 were randomly allocated into two groups:the trail group ( n=68)and the control group(n=67).The trail group received nutritional support treatment ,ω-3PUFA and Gln in combina-tion with chemotherapy .The control group received nutrition support therapy combined with chemotherapy .Results: RR was 38.2%in the trail group and 28.4%in the control group, and there was no statistic difference between the 2 groups (χ2 =1.482,P=0.224).The common adverse reactions were neutropenia , nausea and vomiting, and there was no statis-tic difference between the 2 groups(Z=1.061,0.096,P>0.05); there were 5 patients with neutropenic fever in trail group and 14 in control group,and there was a statistic difference between the 2 groups(χ2 =5.118, P=0.024).Com-pared with control group ,the changes of immunologic indicators before and after chemotherapy such as IgG , IgA, CD4 +, CD8 +, and CD4 +/CD8 +in the trail group improved(t=20.082, 13.585, 34.229, 22.583, 73.021,P<0.001).The changes of hemoglobin before and after chemotherapy of the 2 groups had significant difference (t=19.310,P<0.001). Conclusion:ω-3PUFA and Gln application in patients with chemotherapy could not improve the response rate of chemo -therapy, but could significantly improve the immune status of patients .关键词
肺肿瘤/营养风险/免疫调节营养/ω-3多不饱和脂肪酸/谷氨酰胺Key words
lung neoplasm/nutritional risk/immunomodulatory nutrition/ω-3 polyunsaturated fatty acid/glutamine分类
医药卫生引用本文复制引用
韩东景,赵楠,薛永飞,沈艳丽,马慧利,张蕾..ω-3多不饱和脂肪酸和谷氨酰胺对具有营养风险的晚期肺癌化疗患者的影响[J].郑州大学学报（医学版）,2013,(4):536-539,4.
