郑州大学学报（医学版）Issue(6)：729-731,732,4.DOI:10.3969/j.issn.1671-6825.2013.06.004
浆液性卵巢癌组织中 CD44和 CD24的表达
Expressions of CD44 and CD24 in tissue of serous ovarian cancer
摘要
Abstract
Aim:To detect the expressions of CD 44 and CD24 in serous ovarian cancer .Methods:The expressions of CD44 and CD24 were detected by immunohistochemical staining in 10 cases of normal ovarian tissue and 30 cases of human serous ovarian cancer tissue .Results:The positive expression rates of CD 44 and CD24 in serous ovarian cancer tissue were 66.7%(20/30)and 60.0%(18/30),which were significantly higher than those in normal ovarian tissue [0%(0/10) and 0%(0/10)](P<0.001).CD44 and CD24 expressions were associated with FIGO stage , histological grade and lymph node metastasis (P<0.05).The expressions of CD44 and CD24 were positively correlated with each other in serous ovari-an cancer tissue (rP=0.397,P=0.018).Conclusion:CD44 and CD24 expressions in serous ovarian cancer might pro-mote the development of ovarian cancer and its invasion and metastasis .CD44 and CD24 may have some kind of synergistic effect in progress of serous ovarian cancer .关键词
浆液性卵巢癌/CD44/CD24Key words
serous ovarian cancer/CD44/CD24分类
医药卫生引用本文复制引用
白晶,李爱军,王丽萍,张斌,张毅..浆液性卵巢癌组织中 CD44和 CD24的表达[J].郑州大学学报（医学版）,2013,(6):729-731,732,4.基金项目
国家自然科学基金资助项目81171985，81171986卵巢癌是女性三大恶性肿瘤之一。目前有研究［1］表明细胞黏附分子与肿瘤的发生相关。 CD44是一种糖蛋白，是细胞黏附分子的成员之一，主要位于细胞表面，它在免疫识别、细胞运动、细胞间黏附、细胞与基质间相互作用及淋巴细胞归巢中均起促进作用，是接受细胞外基质糖基化、透明质酸化信息的 （）
