郑州大学学报（医学版）Issue(6)：758-761,4.DOI:10.3969/j.issn.1671-6825.2013.06.012
非小细胞肺癌组织中 Nanog的表达
Expression of Nanog in non-small cell lung cancer tissue
摘要
Abstract
Aim:To investigate the expression of Nanog in non-small cell lung cancer (NSCLC) tissue.Methods:The expressions of Nanog mRNA and protein were detected in the specimens from 106 cases of NSCLC and 10 cases of normal lung tissue by using quantitative real-time PCR and immunohistochemistry , respectively , then the relationship between the expression of Nanog protein and the prognosis of the patients with lung adenocarcinoma ( LAC) or lung squmous cell carci-noma(LSCC) was analyzed by log-rank test.Results:The positive expression rate of Nanog protein in NSCLC tissue was 24.5%,higher than that(0%) in normal lung tissue(P=0.114);the positive expression rate of Nanog protein was higher in LAC tissue than that in LSCC tissue and increased with the increase of pathological degree (χ2 =5.087,6.845,P <0.05);in patients with LAC, those with negative expression of Nanog protein had better progonosis (χ2 =5.352,P=0 .020).The expression level of Nanog mRNA in NSCLC tissue was (0.950 ±0.183),higher than that (0.277 ±0.190) in normal lung tissue(F=122.662,P<0.001);the expression level of Nanog mRNA increased with the increase of patho-logical degree(F=4.047,P=0.020).Conclusion:Nanog expression is relevant to the carcinogenesis and development of NSCLC, besides,the expression of Nanog protein is associated with the prognosis of patients with LAC .关键词
非小细胞肺癌/Nanog/预后Key words
non-small cell lung cancer/Nanog/prognosis分类
医药卫生引用本文复制引用
骆梅青,卜庆,曹轶林,郑桂银,伍爱华..非小细胞肺癌组织中 Nanog的表达[J].郑州大学学报（医学版）,2013,(6):758-761,4.基金项目
广西壮族自治区卫生厅计划课题 Z2011171 （）
