郑州大学学报（医学版）Issue(1)：99-101,102,4.DOI:10.3969/j.issn.1671-6825.2014.01.028
西妥昔单抗联合奈达铂对宫颈癌 Hela 细胞增殖的影响
Effects of nedaplatin combined with cetuximab on proliferation of cervical carcinoma Hela cell line
摘要
Abstract
Aim:To study the effects of nedaplatin (NDP) combined with cetuximab(C225) on the proliferation of cervical carcinoma Hela cell line.Methods:The Hela cells were allocated into C225 groups, NDP groups and combination groups of C225 and NDP(C225+NDP groups).The concentration of C225 groups was 10,20,40,60,80 and 160 mg/L, the concentration of NDP groups was 1,5,10,20,40 and 60 mg/L;and that of C225+NDP groups was 40 mg/L C225 plus NDP at different concentrations .Hela cells were treated for 24 h, 48 h, 72 h.The inhibitory effects of C225 and NDP on the Hela cells were evaluated by MTT .Results:C225 had no inhibitive effects on Hela cells with the increased concentra-tions and time(P>0.05).NDP could significantly inhibited the growth of Hela cells , and the inhibition showed concentra-tion and time dependence and interaction (F=3 200.480,3 057.250, and 99.201,P<0.001).The combination of C225 and DNP had better inhibitive effects on Hela cells than single use of C 225 or NDP(F=39.507,P<0.001).Conclusion:C225 could enhance the inhibition effects of NDP on Hela cell line .关键词
西妥昔单抗/奈达铂/Hela细胞/表皮生长因子受体Key words
cetuximab/nedaplatin/Hela cell line/EGFR分类
医药卫生引用本文复制引用
邓克红,王晨阳,王武亮..西妥昔单抗联合奈达铂对宫颈癌 Hela 细胞增殖的影响[J].郑州大学学报（医学版）,2014,(1):99-101,102,4.基金项目
河南省卫生厅科技攻关项目201203043 （）
