郑州大学学报（医学版）Issue(2)：153-156,157,5.DOI:10.13705/j.issn.1671-6825.2014.02.004
双歧杆菌、酪酸梭菌及谷氨酰胺对慢性应激模型小鼠肠黏膜屏障的影响
Influence of Bifdobacterium inaf ntis, Clostridium butyricum and glutamine on the intestinal barrier in mice following chronic psychological stress
摘要
Abstract
Aim:To determine the influence of chronic psychological stress on intestinal barrier and to investigate the contents of D-lactic and DAO increased significantly in the stress group , while those in Bifdobacterium infantis group, Clos-tridium butyricum group, glutamine group and combination group significantly reduced compared with the stress group espe -cially the combination group(F=5.950,13.214,P<0.001).The expression levels of ZO-1 and Occludin mRNA and pro-tein in the stress group were lower than that in the normal group in small intestine and colon ,which were increased signifi-cantly,in the other intervention groups especially the combination group had the highest expression ( small intestine:F=741.007,511.112,291.083, 6077.64, P<0.001;colon:F=527.769,411.6881, 244.748,583.786,P<0.001).Con-clusion:The disturbance of intestinal function occurs , and intestinal permeability increases in mice suffered from chronic psychological stress .Bifdobacterium infantis, Clostridium butyricum and glutamine could alleviate the disturbance .关键词
双歧杆菌/酪酸梭菌/谷氨酰胺/肠黏膜屏障/小鼠/慢性应激Key words
Bifdobacterium infantis/Clostridium butyricum/glutamine/intestinal barrier/mouse/chronic psychological stress分类
医药卫生引用本文复制引用
王玉玉,张军,郑鹏远,李付广,刘志强,陈东晖..双歧杆菌、酪酸梭菌及谷氨酰胺对慢性应激模型小鼠肠黏膜屏障的影响[J].郑州大学学报（医学版）,2014,(2):153-156,157,5.基金项目
“十二·五”国家科技支撑计划2012BAI35B 03；国家自然科学基金资助项目81370494；“973”前期专项研究基金资助项目2011CB512006；河南省科技创新人才基金资助项目134200510022；郑州市创新型科技人才队伍建设工程基金资助项目131PLJRC656 （）
