郑州大学学报（医学版）Issue(2)：233-236,4.DOI:10.13705/j.issn.1671-6825.2014.02.025
局部晚期宫颈癌组织中 ERCC1 mRNA 表达及 DNA 倍体与新辅助化疗效果的关系
Relationship of expression of ERCC1 mRNA and DNA ploidy in locally advanced cervical cancer tissue to curative effect of neoadjuvant chemo-therapy
摘要
Abstract
Aim:To explore relationship between the effect of neoadjuvant chemotherapy ( NACT) and the expression of ERCC1 mRNA,DNA ploidy in locally advanced cervical cancer ( LACC) tissue.Methods:A total of 60 cases of LACC biopsy specimens before chemotherapy were collected .PCR combined with the fluorescence probe technique were applied to analyze the expression of ERCC 1 mRNA in the specimens , and the DNA quantitative analysis technique was adopted to an-alyze DNA ploidy.Results:Thirty-three cases were effective in the 60 patients, and the effective rate was 55.0%.There was a correlation between ERCC1 mRNA expression, DNA ploidy and the curative effect of NACT(P<0.05).The result of logistic regression showed that high expression of ERCC 1 mRNA was a negative factor for curative effect of NACT [β=-2.672,OR(95%CI) =0.069 (0.008 -0.583)],and DNA diploid was a positive factor [β=1.348,OR(95%CI)=3.850(1.134-13.075)].Conclusion:The expression of ERCC1 mRNA and DNA ploidy in LACC tissue may be related to the sensitivity of NACT .关键词
局部晚期宫颈癌/ERCC1/DNA倍体/新辅助化疗Key words
locally advanced cervical cancer/ERCC1/DNA ploidy/neoadjuvant chemotherapy分类
医药卫生引用本文复制引用
马一鸣,陈红敏,邓君丽,阎夏,窦萌萌,王莉..局部晚期宫颈癌组织中 ERCC1 mRNA 表达及 DNA 倍体与新辅助化疗效果的关系[J].郑州大学学报（医学版）,2014,(2):233-236,4.基金项目
河南省科技攻关计划项目102102310107 （）
