郑州大学学报（医学版）Issue(2)：236-239,4.DOI:10.13705/j.issn.1671-6825.2014.02.026
常用免疫抑制剂治疗对系统性红斑狼疮患者淋巴细胞亚群的影响
Changes of lymphocyte subsets in systemic lupus erythematosus patients after common immunosuppressant therapy
摘要
Abstract
Aim: To investigate the changes of peripheral blood lymphocyte subsets in systemic lupus erythemaosus ( SLE) patients with therapy of common immunosuppressant ( prednisolone and CTX or MMF ) .Methods:The lymphocyte subsets of 83 patients with SLE (24 without therapy and 59 with therapy) and 30 healthy controls were chosen and the pro-portion of T cells , B cells and NK cells in peripheral blood was measured with flow cytometry .Results:The percentage of CD3 +CD4 +Th cells(t=8.061,P<0.001), CD3 -CD16 +CD56 +NK cells(Z=3.637,P<0.001) and the Th/Ts ratio (Z=6.880,P<0.001) were significantly lower in SLE patients than those in controls , while CD3 +CD8 +Ts cells(t=5.552,P<0.001) and CD3 -CD19 +B cells(Z=2.500,P=0.012) were higher than those in controls.Compared with those without therapy, CD3 +T cells in patients with therapy increased, but the change was not obvious (t=1.802,P=0.075).In comparison, the CD3 +CD4 +Th cells increased significantly(t=2.581,P=0.012), so did the Th/Ts ratio (Z=2.205,P=0.027).CD3 -CD19 +B cells in those with therapy were obviously fewer than those without therapy (Z=2.151,P=0.031).Conclusion:The imbalance of lymphocyte subsets is common in SLE patients , which could involve in the pathogenesis of SLE .Compared with those without therapy , the combined therapy of prednisolone and CTX or MMF could regulate the Th/Ts ratio effectively and suppress B cells selectively , by which they contribute to the balance of lym-phocyte subsets in SLE patients .关键词
系统性红斑狼疮/淋巴细胞亚群/免疫抑制剂Key words
systemic lupus erythematosus/lymphocyte subset/immunosuppressant分类
医药卫生引用本文复制引用
苏利沙,张根豪,邓少丽,张俊华,刘红春..常用免疫抑制剂治疗对系统性红斑狼疮患者淋巴细胞亚群的影响[J].郑州大学学报（医学版）,2014,(2):236-239,4.基金项目
国家自然科学基金81101199；河南省教育厅自然科学基金资助项目12A320035 （）
