化工进展Issue(12)：2982-2987,6.DOI:10.3969/j.issn.1000-6613.2013.12.033
9,10-环亚甲基假紫罗兰酮的响应面法合成
Synthesis of 9,10-cyclomethylene pseudoionone with response surface method
摘要
Abstract
The 9,10-cyclomethylene pseu doionone was obtained through Simmons-Smith reaction using pseudoionone and halogenated hydrocarbons as raw materials. The structure of product was determined by IR , GC and GC-MS. Effects of different factors on the yield of product were investigated,including the amount and species of catalyst,and reaction temperature. The best condition was as follows:n(pseudoionone)∶n(diiodomethane)∶n(diethyl zinc)=1∶1∶1.8,ice bath time 4.7 h,reflux time 5.2 h,ice bath temperature-5 ℃,reaction solvent dichloromethane,and pseudoionone’s molar concentration of 0.2 mol/L,under which the yield of 9,10-cyclomethylene pseudoionone reached 76.2%.关键词
Simmons-Smith反应/响应面法/9,10-环亚甲基假紫罗兰酮Key words
Simmons-Smith reaction/response surface method/9,10-cyclomethylene pseu doionone分类
化学化工引用本文复制引用
赵扬,罗金岳..9,10-环亚甲基假紫罗兰酮的响应面法合成[J].化工进展,2013,(12):2982-2987,6.基金项目
江苏省普通高校研究生科研创新计划（CXLX11_0539）及江苏高校优势学科建设工程项目。 （）
