化工进展Issue(2)：423-428,6.DOI:10.3969/j.issn.1000-6613.2014.02.027
N-甲基-N,N-双十二烷基壳聚糖盐酸盐的合成及自组装囊泡性能
Preparation and self-assembly property of N-methyl-N,N-didodecyl chitosan
摘要
Abstract
N-methyl-N,N-didodecyl chitosan (TMC) was synthesized. The obtained chitosan derivative was characterized by FTIR , EA and solubility method. N-methyl-N,N-didodecyl chitosan self-assembled vesicles were prepared by the ethanol injection method. Zeta potential of the vesicles ranged from 39.5 mV to 49.5 mV,particle diameter ranged from 50 nm to 100 nm,diameter distribution ranged from 0.17 to 0.26,and the vesicles were very stable for a period of 30 days. The Langmuir behavior of TMC indicated that the lower the pH,the easier the self-assembly. Different pH values of preparation medium had a large effect on the particle size and drug release behavior of the vesicles. However,different pH values of release medium had little effect on the drug release behavior.关键词
表面活性剂/纳米粒子/囊泡/粒度分布/乙醇注射法Key words
surfactants/preparation/nanoparticles/vesicles/ethanol injection分类
化学化工引用本文复制引用
洪键淞,辛梅华,李明春,方江海..N-甲基-N,N-双十二烷基壳聚糖盐酸盐的合成及自组装囊泡性能[J].化工进展,2014,(2):423-428,6.基金项目
福建省重点科技项目（2009H0030）、福建省自然科学基金（2011J01312和2012J01396）及科技部科技人员服务企业项目（2009GJC40030）。 （）
