哈尔滨商业大学学报（自然科学版）Issue(2)：133-137,5.
丁香苦苷单体与丁香苦苷 PLGA 纳米粒药动学比较
Comparative study on pharmacokinetics of syringopicroside monomer and syringopicroside PLGA -nanoparticles
摘要
Abstract
This paper determined the content of syringopicroside in the plasma of rats and to make a comparative study on pharmacokinetics of syringopicroside monomer with anti -HBV function and syringopicroside PLGA -nanoparticles in the vivo of rats .Chromatographic col-umn:Diamonsil C18(5 μm,250 ×4.6 mm)mobile phase: methanol-water(50∶50,V/V);flow rate:1.0 mL/min;detected wavelength:221 nm;sample amount:20 μL.The concen-tration of syringopicroside in the plasma of Wistar rats was measured at different time points after intravenous injection .The T1/2αand T1/2βvalues of syringopicroside polylactic -co-gly-colic acid-nanoparticles were 2.25 times and 1.23 times of that of the syringopicroside so-lution respectively with the same dose ( 10 mg/mL ) .The AUC value of syringopicroside polylactic-co-glycolic acid-nanoparticles was 3.09 times of that of syringopicroside solu-tion and the plasma clearance rate of syringopicroside polylactic -co-glycolic acid-nanop-articles was one third of that of syringopicroside .Through the data fitting method , it was found that both syringopicroside monomer and syringopicroside polylactic -co-glycolic acid-nanoparticles in rats conformed to the two -compartment model .The SYR-PLGA-NP changed the feature of pharmacokinetics in the body of rats by making the syringopicroside remain relatively high concentration in plasma for a longer period ,having a slow -releasing effect.关键词
丁香苦苷/丁香苦苷-PLGA纳米粒/药动学/高效液相色谱法Key words
syringopicroside/syringopicroside polylactic -co -glycolic acid -nanoparti-cles/pharmacokinetics/HPLC分类
医药卫生引用本文复制引用
李爽,吕邵娃,李永吉,杨志欣,赵义军..丁香苦苷单体与丁香苦苷 PLGA 纳米粒药动学比较[J].哈尔滨商业大学学报（自然科学版）,2014,(2):133-137,5.基金项目
高等学校博士学科点专项科研基金 （）
