华南农业大学学报Issue(4)：553-557,5.
人参皂苷 Rb3对糖尿病模型小鼠的降血糖和抗氧化作用
Effects of Ginsenoside Rb3 on Antihyperglycemia and Antioxidation in Diabetic Mice
摘要
Abstract
In order to investigate the role of ginsenoside Rb 3 in the therapy of diabetes and its mecha-nisms, the streptozocin-induced diabetic mice model was constructed and the effects of ginsenoside Rb 3 on serum glucose , serum lipid , insulin and antioxidative indices were systematically studied .The detec-tion of fasting blood glucose levels indicated that 14 d treatment with ginsenoside Rb 3 via intragastric ad-ministration had a significant ( P<0 .01 ) hypoglycemic activity on diabetic mice and the concentration of 30 mg· kg -1 had more effective therapy results , which was equivalent to that of diabetic medicine met-formin hydrochloride .The effects of ginsenoside Rb 3 on serum total cholesterol ( TC ) , glycerin trimyr-istate ( TG) and insulin ( INS) were analyzed and the results showed that the Rb 3 had a significant regula-tory function to decrease the concentration of serum lipid , which increased that of insulin in diabetic mice.The dose of 30 mg· kg -1 Rb3 was more effective than that of metformin hydrochloride .The antiox-dative effects of Rb 3 were evaluated and the results illustrated that the activity of superoxide dismutase (SOD) had greatly increased, while the content of malonaldehyde (MDA) had obviously decreased in In order to investigate the role of ginsenoside Rb 3 in the therapy of diabetes and its mecha-nisms, the streptozocin-induced diabetic mice model was constructed and the effects of ginsenoside Rb 3 on serum glucose , serum lipid , insulin and antioxidative indices were systematically studied .The detec-tion of fasting blood glucose levels indicated that 14 d treatment with ginsenoside Rb 3 via intragastric ad-ministration had a significant ( P<0 .01 ) hypoglycemic activity on diabetic mice and the concentration of 30 mg· kg -1 had more effective therapy results , which was equivalent to that of diabetic medicine met-formin hydrochloride .The effects of ginsenoside Rb 3 on serum total cholesterol ( TC ) , glycerin trimyr-istate ( TG) and insulin ( INS) were analyzed and the results showed that the Rb 3 had a significant regula-tory function to decrease the concentration of serum lipid , which increased that of insulin in diabetic mice.The dose of 30 mg· kg -1 Rb3 was more effective than that of metformin hydrochloride .The antiox-dative effects of Rb 3 were evaluated and the results illustrated that the activity of superoxide dismutase (SOD) had greatly increased, while the content of malonaldehyde (MDA) had obviously decreased in diabetic mice after the treatment of Rb 3 , which was significant in improving the antioxdative ability and relieving diabetic complication .关键词
人参皂苷Rb3/降血糖/降血脂/抗氧化/小鼠Key words
ginsenoside Rb 3/antihyperglycemia/reduction of serum lipid/antioxidation/mice分类
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孟凡丽,苏晓田,郑毅男..人参皂苷 Rb3对糖尿病模型小鼠的降血糖和抗氧化作用[J].华南农业大学学报,2013,(4):553-557,5.基金项目
吉林省科技发展计划重点项目 （）
