华西口腔医学杂志Issue(6)：615-618,4.DOI:10.7518/hxkq.2013.06.017
分泌型卷曲相关蛋白1与慢性牙周炎的相关分析
Exploring the relationship between secreted frizzled-related protein 1 and chronic periodontitis
摘要
Abstract
Objective This study detects the expression of secreted frizzled-related protein 1 (SFRP1) in healthy patients and patients with chronic periodontitis (CP) and explores the relationship between SFRP1 and the occurrence and development of CP. Methods First, 28 patients forming the CP group were further divided into mild, moderate, and severe CP subgroups according to clinical attachment loss (CAL) data. Ten healthy volunteers were recruited in the control group. Gingival crevi-cular fluid (GCF) was collected from all of the patients, and the concentration of SFRP1 in the GCF samples was detected using enzyme-linked immunosorbent assay. Next, gingival lesions were obtained from 22 patients in the CP group and healthy gingival tissues were obtained from the 10 healthy patients in the control group. Immunohistochemical analysis for SFRP1 was used to analyze the correlation between the expression of SFRP1 and the severity of CP based on staining intensities. Results The concentration of SFRP1 in GCF samples taken from of the CP group (281.07 ng·L-1±33.37 ng·L-1) was signifi-cantly higher than that in samples taken from the control group (245.30 ng·L-1±35.69 ng·L-1) (P<0.05). A significant positive correlation was observed between the concentration of SFRP1 in GCF and CAL (r=0.651, P<0.001). Furthermore, the SFRP1 scores in the CP groups (4.500±0.913) were significantly higher than those in the control group (2.800±1.135) (P<0.001). SFRP1 scores did not vary significantly among the CP subgroups (P>0.05). Conclusion SFRP1 expression in the CP groups was significantly higher than that in the control group. Thus, SFRP1 may play a significant role in the development of CP.关键词
慢性牙周炎/龈沟液/分泌型卷曲相关蛋白1Key words
chronic periodontitis/gingival crevicular fluid/secreted frizzled-related protein 1分类
医药卫生引用本文复制引用
袁海波,方厂云,阙国鹰,彭解英,金晶,许春姣,邱喜丽,王璐,吕逢源,刘婷婷,吴颖芳,尹晓敏..分泌型卷曲相关蛋白1与慢性牙周炎的相关分析[J].华西口腔医学杂志,2013,(6):615-618,4.基金项目
湖南省科技厅基金资助项目 （）
