江汉大学学报（自然科学版）Issue(5)：76-80,5.
短肽RADA16-1自组装纤维长度与止血关系研究
Relationship Between Fiber Length and Hemostasis of Self-assembled Peptide RADA16-1
摘要
Abstract
Objective:A self-assembled small peptide RADARADARADARADA(RADA16-1) can form a long fiber hydrogel,which has the function of surgical hemostasis,to explore the long fi-ber assemble dynamics and hemostasis mechanism of peptide RADA16-1. Methods:Through circu-lar dichroism spectrum,atomic force characterization and rheological mechanics analysis,kinetics of long fiber self-assemble had been studied. Hemostatic models of spinal cord injury and liver trau-ma were established to study the effect of blooding control. Results:The results of circular dichroism spectrum indicated that RADA16-1 in solution was beta folding characteristics both before and after ultrasound. The results of atomic force characterization and rheological mechanics analysis showed that RADA16-1 can self-assemble into long fiber which length was about(786. 34 ± 96. 54)nm, and the long fiber assembled process of RADA16-1 was positively associated with time after ultra-sound. Meanwhile,a negative correlation was detected between the long fiber length and the bleed-ing time in animal models. Conclusion:The small peptide RADA16-1 solution can rapidly situ hy-drogelize to long fiber form,can be used in surgery as hemostatic.关键词
RADA16-1/止血/圆二色谱/原子力显微镜/流变力学Key words
RADA16-1/hemostasis/circular dichroism/atomic force microscopy/rheology分类
医药卫生引用本文复制引用
李佳楠,钟小忠,王婷..短肽RADA16-1自组装纤维长度与止血关系研究[J].江汉大学学报（自然科学版）,2013,(5):76-80,5.基金项目
湖北省教育厅项目 （）
