摘要
Abstract
Objective:To explore the distribution and antibiotic resistance of extended-spec-trum-β-lactamases(ESBLs)-producing Escherichia coli in the hospital,so as to provide reference for reasonable utilization of antibiotic and reducing of drug resistance. Methods:From Aug,2010 to Dec,2011,264 E.colis were isolated from clinical specimens,the antibiotic susceptibility was test-ed by K-B method. According to CLSI standard,ESBLs was confirmed,statistical analysis was tak-en with WHONET 5.4 software. Results:Among 264 E.coli isolates,134(50. 8%)were ESBLs-pro-ducing strains. The sputum was the highest sources of specimens(47. 76%),the department of gen-eral surgery was the highest section-office of distribution(12. 61%). The resistance rates for ES-BLs-producing E.coli to imipenem,meropenem,piperacillin/tazobactam,cefoperazone/sulbactam, amikacin,cefoxitin and nitrofurantoin were lower and between 0% to 15. 5%;The resistance rates to ciprofloxacin,levofloxacin,gentamicin,compound sulfamethoxazole and amoxicillin/clavulanate were higher and between 41. 3% to 82. 8%;The resistance rates to penicillins,cephalosporins and aztreonams were highest and reached 100%,so they are not suitable for clinic. Conclusion:ES-BLs-producing E.coli has multidrug-resistant,so it is necessary to strengthen the surveillance in clinical laboratory,to use antibiotics according to antibiotic susceptibility test.关键词
产超广谱β-内酰胺酶/大肠埃希菌/耐药性/监测Key words
extended-spectrum-β-lactamases-producing/Escherichia coli/drug resis-tance/surveillance分类
医药卫生
