中国健康心理学杂志Issue(7)：983-985,3.DOI:10.13342/j.cnki.cjhp.2014.07.010
迟发性运动障碍患者血清褪黑素水平
Serum Melatonin Levels in Schizophrenic Patients with Tardive Dyskinesia
阎同军 1王彦彦 1陈方斌 1徐乐平1
作者信息
- 1. 中国.解放军第102医院精神科 常州 213003
- 折叠
摘要
Abstract
Objective To investigate the possible roles of melatonin ( MT) in the pathophysiology of tardive dyskinesia ( TD) in schizo-phrenic patients.Methods A total of 32 cases of schizophrenic patients with TD (TD group)and 32 schizophrenic patients without TD (non-TD group)were recruited.The levels of serum MT,superoxide dismutase(SOD)and malondialdehyde(MDA)were measured.The severities of TD were assessed by abnormal involuntary movement scale ( AIMS) .Results The concentration of MT in the TD group was significantly lower compared with non -TD group(t=2.403,P<0.05).TD patients had significantly lower levels of SOD (t=2.318,P<0.05)and higher levels of MAD(t=5.011,P<0.001)than non-TD schizophrenic patients.The total scores of AIMS in TD group were negatively correlated with levels of MT(r=-0.396,P<0.05) and positively correlated with levels of MDA(r=0.431,P<0.05). A positive relationship between levels of MT&SOD (r=0.361,P<0.05)and a negative relationship between levels of MT&MDA (r=0.469,P<0.01)were found in TD group.Conclusion Melatonin may be involved in the pathological process of TD in schizophrenic patients,which has relationships with oxidative stress .关键词
迟发性运动障碍/精神分裂症/褪黑素/超氧化物歧化酶/丙二醛Key words
Tardive dyskinesia/Schizophrenia/Melatonin/Superoxide dismutase/Malondialdehyde分类
医药卫生引用本文复制引用
阎同军,王彦彦,陈方斌,徐乐平..迟发性运动障碍患者血清褪黑素水平[J].中国健康心理学杂志,2014,(7):983-985,3.
