中国健康心理学杂志Issue(7)：993-995,3.DOI:10.13342/j.cnki.cjhp.2014.07.014
利培酮合并氟哌啶醇治疗精神分裂症激越行为
Effectiveness of Risperidone Combining Short-term Intramuscular Haloperidol in the Treatment of the Agitated Behavior of Psychotic Patients
摘要
Abstract
Objective To explore the efficacy and adverse events of risperidone combining short-term intramuscular haloperidol or clonazepam and intramuscular haloperidol in the treatment of the agitated behavior of patients in the acute phase of schizophrenia .Meth-ods 165 patients associated with impulsive behavior who met the diagnostic criteria of CCMD -3 for schizophrenia were randomly divid-ed into three groups .Group A was treated with risperidone combining short-term intramuscular haloperidol ,B with risperidone combining short-term intramuscular donazepam and C with only haolperidol for 2 weeks.The efficacy and adverse events were evaluated by PANSS and TESS.Results After treatment,compared to baseline ,the factor-scores of excitement of PANSS in each group were reduced signifi-cantly.There were significant differences between the three groups on the score of the factor -scores of excitement of PANSS by the end of 1st week((F=5.41,P<0.01),and the efficacy of the group A and C was better than that of group B .At the meanwhile no significant differences were found between the three group when taking the reduce rate of factor -scores of excitement of PANSS as the standard of ef-ficacy level by the end of 5th day(χ2 =1.526,P>0.05),1st week(χ2 =1.529,P>0.05)and 2nd week(χ2 =1.335,P>0.05).There were significant differences between three groups on the incidence rate of extrapyramidal symptoms ,such as myotonia(χ2 =22.388,P<0.01),tremor(χ2 =8.633,P<0.05),torsion dystonia(χ2 =1.335,P<0.05) and drug-induced akathisia (χ2 =6.341,P<0.05). Conclusion Risperidone combined short-term haloperidol intramuscular can greatly improve patient's tolerability and control agitated behavior of patients in the acute phase of schizophrenia quickly and efficiently .It can be a good means for them .关键词
精神分裂症/激越行为/利培酮/氯硝安定/氟哌啶醇/短期肌注Key words
Schizophrenia/Agitated behavior/Risperidone/Clonazepam/Haloperidol/Short-term intramuscular分类
医药卫生引用本文复制引用
刘云,刘锟,孙建中,孙亚军,焦小雷,陈金山..利培酮合并氟哌啶醇治疗精神分裂症激越行为[J].中国健康心理学杂志,2014,(7):993-995,3.基金项目
安徽省卫生厅医学科研项目 （）
