计算机工程与应用Issue(8)：226-230,264,6.DOI:10.3778/j.issn.1002-8331.1311-0269
计算甘油代谢目标函数的一种新算法
New algorithm for computing objective function of glycerol metabolism
摘要
Abstract
Flux balance analysis is an effective tool that can quantitatively predict the flux distribution of cellular metabo-lism in the study of metabolic engineering. The accuracy of this kind of predictions can be achieved by computing a rea-sonable objective function. This paper considers the problem of computing an objective function of glycerol metabolism in Klebsiella pneumoniae for 1, 3-propanediol production. The mathematical representation of this problem is a bilevel programming model. The dual theory of linear programming is firstly used to transform the above bilevel programming into an equivalent nonlinear optimization problem. Then the obtained problem can be solved by nonlinear optimization algo-rithms. Compared with the current method, the proposed approach obtains the globally optimal flux distribution of glycerol metabolism in Klebsiella pneumoniae for 1, 3-propanediol production.关键词
优化/通量平衡分析/双层规划/对偶理论/代谢/1,3-丙二醇/甘油Key words
optimization/flux balance analysis/bilevel programming/duality theory/metabolism/1, 3-propanediol/glycerol分类
数理科学引用本文复制引用
徐恭贤,苏丹..计算甘油代谢目标函数的一种新算法[J].计算机工程与应用,2014,(8):226-230,264,6.基金项目
国家自然科学基金（No.11101051，No.11371071）；辽宁省高等学校优秀人才支持计划资助项目（No.LJQ2013115）。 （）
