军事医学Issue(1)：26-30,5.DOI:10.7644/j.issn.1674-9960.2014.01.008
CBLB502对放射性肺炎和肺纤维化的防护作用研究
CBLB502 Protects mice radiation pneumonitis and pulmonary fibrosis
摘要
Abstract
Objective To investigate the protective effect of CBLB 502 on radiation pneumonitis and pulmonary fibrosis for confirming the feasibility of CBLB502 as a clinical anti-radiation drug release.Methods With a single 20 Gy irradia-tion, C57BL/6J mice was sacrificed on 24 h, 1 month, 3 months and 5 months and lung tissue was assayed by TUNEL method for apoptosis of alveolar epithelial cells and endothelial cells , HE staining showing fibrosis changes , immunohisto-chemistry detecting the expression of specific indicators , as well as pathological changes of the fur and skin radiated site . Results CBLB502 inhibits apoptosis in mice alveolar epithelial cells and vascular endothelial cells after irradiation , slowing the process of pulmonary fibrosis , while reducing the expression of laminin and maintaining the expression of surfac-tant protein B, and the skin inflammation also significantly reduced .Conclusion CBLB502 could alleviate the occurrence of radiation pneumonitis and pulmonary fibrosis as well as radiation-induced skin injury .关键词
TLR5/CBLB502/放射性肺炎/肺纤维化/胸部放射治疗Key words
TLR5/CBLB502/radiation pneumonitis/pulmonary fibrosis/thoracic radiotherapy分类
医药卫生引用本文复制引用
乔玉磊,王治东,夏金凤,田喜凤,张学清,周仕香,刘海翔,陈英..CBLB502对放射性肺炎和肺纤维化的防护作用研究[J].军事医学,2014,(1):26-30,5.基金项目
北京市自然科学基金资助项目 （）
