军事医学Issue(1)：48-52,5.DOI:10.7644/j.issn.1674-9960.2014.01.013
APE1、XRCC1基因多态性对肝癌易感性及铂类药物敏感性的影响
Single-nucleotide polymorphisms in DNA repair genes APE1 and XRCC1 and suscep-tibility to hepatocellular carcinoma and their correlation with sensitivity of platinum chemotherapy in HCC
摘要
Abstract
Objective To investigate the relationship between APE1, XRCC1 gene polymorphisms and hepatocellular carcinoma(HCC) susceptibility and to explore the correlation of APE1, XRCC1 gene polymorphisms with the sensitivity to platinum-based drugs .Methods Seventy-eight HCC patients and 80 controls were selected .By PCR and RFLP , the single nucleotide polymorphism of APE1 Asp148Glu and XRCC1 Arg194Trp genes and the susceptibility of HCC or platinum drug sensitivity were analyzed.Results The Glu/Glu genotype of APE1 could increase in the risk of HCC by 7.21 times (95%CI:1.325-29.109) (P<0.05).APE1 and XRCC1 gene polymorphisms could also affect the platinum drug resistance of HCC patients.Conclusion APE1 Asp148Glu is correlated with the susceptibility to HCC .APE1 and XRCC1 genes can be considered a target for therapy to improve the sensitivity of HCC platinum drugs .关键词
基因多态性/肝细胞癌/易感/铂类药物敏感性Key words
polymorphism ,gene/hepatocellular carcinoma/susceptibility/platinum drug sensitivity分类
医药卫生引用本文复制引用
方壮伟,周开伦,谢贤和,梁茱,吴宁,邱纯,林福煌,袁波,彭永红,符勇,周卫平..APE1、XRCC1基因多态性对肝癌易感性及铂类药物敏感性的影响[J].军事医学,2014,(1):48-52,5.基金项目
海南省自然科学基金资助项目 （）
