江西农业大学学报Issue(6)：1248-1254,7.
中药提取物对猪源耐药大肠杆菌分离株的抑制作用
AntiMICrobial Activities of Chinese Herb Extracts against Antibiotic-resistant Isolates of E.Coli from Swine Farms
摘要
Abstract
This study was conducted to screen out some Chinese herbs with strong anti MICrobial activity and provide basis for developing bacteriostatic Chinese berbal compounds .The aqueous and neutral ethanol ex-tracts of 29 kinds of Chinese herbs were prepared ,respectively,and then their antiMICrobial activities against 10 isolated strains of antibiotic-resistant E.Coli and 3 type strains of E.Coli were evaluated by determining di-ameter of inhibition zone ( IZD,mm) and minimal inhibitory concentration ( MIC,mg/mL) .Three extracts from Galla Chinensis,Fructus forsythiae and Fructus crataegi had antiMICrobialactivity to 13 strains of the tested E. Coli, and extracts from Sanguisorba officinalis,Scutellaria baicalensis,Punica granatum,Fraxinus rhynchophylla,Coptis chinensis,Rheum officinale,Gardenia jasminoides,and Folium isatidis had antimicrobial activity to some of the tested strains;the IZD of ethanol extract from Galla chinensis was higher than 20 mm against all of the tested strains,and that of two extracts from Fructus forsythiae were 10.0 to 14.0 mm.The MIC value of the etha-nol extract from Galla chinensis was 15.6 mg/mL,while that of its aqueous extract was 125 to 250 mg/mL a-gainst 13 tested strains,which indicated that the ethanol extract had the strongest anti MICrobial activity;the two extracts of Forsythia suspensa with MIC values of 125 to 250 mg/mL had a secondary anti MICrobial activi-ty;the MIC values of the ethanol extract from Fructus crataegi was 125 to 250 mg/mL against 13 tested strains , and that of its aqueous extract was 250 to 500 mm against the tested strains except for SEC 616, SEC911, C193,and C197.Sanguisorba officinalis,Scutellaria baicalensis,Fraxinus rhynchophylla,and Rheum officinale had higher MIC values.The MIC value of the aqueous extract from Folium isatidis was 250 to 500 mg/mL.Ex-tracts from Galla chinensis and Forsythia suspensa had strongest anti MICrobial activity against 13 tested E.Coli strains,and the extracts from Fructus crataegi,Fraxinus rhynchophylla,Rheum officinale,Folium isatidis,Coptis chinensis,and Scutellaria baicalensis had activity to some of the tested strains .关键词
耐药性/大肠杆菌/中药/抑制作用Key words
antibiotic-resistance/E.Coli/Chinese herbs/inhibitory effect分类
农业科技引用本文复制引用
肖莉春,孔祥峰,黄名钱,郭小权..中药提取物对猪源耐药大肠杆菌分离株的抑制作用[J].江西农业大学学报,2013,(6):1248-1254,7.基金项目
中国科学院知识创新工程重要方向项目（ KZCX2-EW-411，KSCX2-EW-G-16）、江西省青年科学家培养对象项目（20122BCB23022）和江西省科技支撑计划资助项目 （）
